Home›Labetalol Hydrochloride›Labetalol Hydrochloride + Verapamil

Does Labetalol Hydrochloride Interact with Verapamil?

Labetalol Hydrochloride and Verapamil have a contraindicated drug interaction according to U.S. FDA drug labeling data. Coadministration is contraindicated. Non-dihydropyridine calcium-channel antagonist that can increase risk of bradycardia or hypotension. The mechanism involves additive effects on atrioventricular conduction and heart rate. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Labetalol Hydrochloride Class
beta-Adrenergic Blocker
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Labetalol Hydrochloride and Verapamil occurs because additive effects on atrioventricular conduction and heart rate. Clinically, this means coadministration is contraindicated. non-dihydropyridine calcium-channel antagonist that can increase risk of bradycardia or hypotension. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Labetalol Hydrochloride and your doctor is considering prescribing Verapamil (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Labetalol Hydrochloride(Labetalol Hydrochloride)+💊 Verapamil

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
beta-Adrenergic Blocker
Drug B class
—
Source
NLP:labetalol hydrochloride

What this means in plain English

Coadministration is contraindicated. Non-dihydropyridine calcium-channel antagonist that can increase risk of bradycardia or hypotension.

What the FDA label says

"Additive effects on atrioventricular conduction and heart rate"

📖 Source: NLP:labetalol hydrochloride

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Labetalol Hydrochloride and Verapamil against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.