Does Lamivudine And Zidovudine Interact with Zalcitabine?
CDI records a contraindicated classification for Lamivudine And Zidovudine and Zalcitabine. The stored summary is: Use in combination with lamivudine and zidovudine is not recommended due to potential inhibition of intracellular phosphorylation of one another. The mechanism involves may inhibit the intracellular phosphorylation of one another. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Lamivudine And Zidovudine Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
May inhibit the intracellular phosphorylation of one another
What To Tell Your Doctor or Pharmacist
If you are taking Lamivudine And Zidovudine and your doctor is considering prescribing Zalcitabine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider