Does Lidothol Es Patch Interact with Mexiletine?
Lidothol Es Patch and Mexiletine have a moderate drug interaction according to U.S. FDA drug labeling data. Use with caution due to additive and potentially synergistic toxic effects when combined with lidocaine. The mechanism involves additive and synergistic toxicity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Lidothol Es Patch Class
- Amide Local Anesthetic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Lidothol Es Patch and Mexiletine occurs because additive and synergistic toxicity. Clinically, this means use with caution due to additive and potentially synergistic toxic effects when combined with lidocaine. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Lidothol Es Patch and your doctor is considering prescribing Mexiletine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider