Does Linezolid Interact with Tapentadol Hydrochloride?
The NUCYNTA label names linezolid as a monoamine oxidase inhibitor. It warns of serotonin syndrome or opioid toxicity with MAOI interactions and contraindicates NUCYNTA during MAOI use or within the preceding 14 days.
Label evidence and limitations
Named-drug label evidence. The label’s contraindication supports a strong warning for the specified product. Patients should ask their prescriber or pharmacist about their medicines rather than adjust treatment themselves.
Product scope: NUCYNTA oral tapentadol tablets.
Read the DailyMed label: These highlights do not include all the information needed to use NUCYNTA ® TABLETS safely and effectively. See full prescribing information for NUCYNTA ® TABLETS. NUCYNTA ® (tapentadol) tablets for oral use C-II Initial U.S. Approval: 2008
Section: 7 Drug Interactions — Monoamine Oxidase Inhibitors. Compared version 7, label date 2025-12-30. The linked label may be updated after this comparison.
This comparison uses the label identifier saved with the CDI record. The compared version may be newer than the original extraction.
AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.
- Stored CDI classification
- Contraindicated
- Linezolid Class
- Oxazolidinone Antibacterial
- Management
- Confirm exact products with your pharmacist
- Data Source
- Product label via NLM DailyMed
What To Tell Your Doctor or Pharmacist
If you are taking Linezolid and your doctor is considering prescribing Tapentadol Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider