Home›Lopinavir And Ritonavir›Lopinavir And Ritonavir + Fluconazole

Does Lopinavir And Ritonavir Interact with Fluconazole?

Lopinavir And Ritonavir and Fluconazole have a unknown drug interaction according to U.S. FDA drug labeling data. Based on known metabolic profiles, clinically significant drug interactions are not expected between lopinavir and ritonavir and dapsone, trimethoprim/sulfamethoxazole, azithromycin, erythromycin, or fluconazole. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Lopinavir And Ritonavir Class
Protease Inhibitor
Fluconazole Class
Azole Antifungal
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Lopinavir And Ritonavir and your doctor is considering prescribing Fluconazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Lopinavir And Ritonavir(Kaletra)+💊 Fluconazole(Diflucan)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Protease Inhibitor
Drug B class
Azole Antifungal
Source
FDA drug label - lopinavir and ritonavir

What this means in plain English

Based on known metabolic profiles, clinically significant drug interactions are not expected between lopinavir and ritonavir and dapsone, trimethoprim/sulfamethoxazole, azithromycin, erythromycin, or fluconazole.

About Lopinavir And Ritonavir and Fluconazole

Lopinavir And Ritonavir is a Protease Inhibitor, while Fluconazole is an Azole Antifungal. You may recognize them by the brand names Kaletra and Diflucan. Lopinavir And Ritonavir is taken by mouth, whereas Fluconazole is given by intravenous (IV) infusion.

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Lopinavir And Ritonavir and Fluconazole against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.