Does Losartan Potassium And Hydrochlorothiazide Interact with Lisinopril?
Losartan Potassium And Hydrochlorothiazide and Lisinopril have a major drug interaction according to U.S. FDA drug labeling data. Combined use did not provide additional benefit versus monotherapy but increased incidence of hyperkalemia and acute kidney injury. The mechanism involves dual ras blockade increases hyperkalemia and acute kidney injury risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Losartan Potassium And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Losartan Potassium And Hydrochlorothiazide and Lisinopril occurs because dual ras blockade increases hyperkalemia and acute kidney injury risk. Clinically, this means combined use did not provide additional benefit versus monotherapy but increased incidence of hyperkalemia and acute kidney injury. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Losartan Potassium And Hydrochlorothiazide and your doctor is considering prescribing Lisinopril (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider