Does Losartan Potassium And Hydrochlorothiazide Interact with Lisinopril?
CDI records a major classification for Losartan Potassium And Hydrochlorothiazide and Lisinopril. The stored summary is: Combined use did not provide additional benefit versus monotherapy but increased incidence of hyperkalemia and acute kidney injury. The mechanism involves dual ras blockade increases hyperkalemia and acute kidney injury risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Losartan Potassium And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Dual RAS blockade increases hyperkalemia and acute kidney injury risk
What To Tell Your Doctor or Pharmacist
If you are taking Losartan Potassium And Hydrochlorothiazide and your doctor is considering prescribing Lisinopril (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider