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Does Macrolide Antibiotics Eg Erythromycin Interact with Benzhydrocodone And Acetaminophen?

Macrolide Antibiotics Eg Erythromycin and Benzhydrocodone And Acetaminophen have a major drug interaction according to U.S. FDA drug labeling data. CYP3A4 inhibitors increase hydrocodone plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation. The mechanism involves cyp3a4 inhibition increases hydrocodone plasma concentration. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Macrolide Antibiotics Eg Erythromycin and Benzhydrocodone And Acetaminophen occurs because cyp3a4 inhibition increases hydrocodone plasma concentration. Clinically, this means cyp3a4 inhibitors increase hydrocodone plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Macrolide Antibiotics Eg Erythromycin and your doctor is considering prescribing Benzhydrocodone And Acetaminophen (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Macrolide Antibiotics Eg Erythromycin+💊 Benzhydrocodone And Acetaminophen(Apadaz)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:benzhydrocodone and acetaminophen

What this means in plain English

CYP3A4 inhibitors increase hydrocodone plasma concentration, resulting in increased or prolonged opioid effects including respiratory depression and sedation.

What the FDA label says

"CYP3A4 inhibition increases hydrocodone plasma concentration"

📖 Source: NLP:benzhydrocodone and acetaminophen

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.