Home›Magnesium Sulfate Heptahydrate›Magnesium Sulfate Heptahydrate + Propofol

Does Magnesium Sulfate Heptahydrate Interact with Propofol?

Magnesium Sulfate Heptahydrate and Propofol have a major drug interaction according to U.S. FDA drug labeling data. Potentiation and prolongation of analgesia and CNS depression is possible. Monitor depth of CNS depression frequently and adjust dosage accordingly. The mechanism involves antagonism of n-methyl-d-aspartate (nmda) by magnesium sulfate. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Propofol Class
General Anesthetic
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Magnesium Sulfate Heptahydrate and Propofol occurs because antagonism of n-methyl-d-aspartate (nmda) by magnesium sulfate. Clinically, this means potentiation and prolongation of analgesia and cns depression is possible. monitor depth of cns depression frequently and adjust dosage accordingly. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Magnesium Sulfate Heptahydrate and your doctor is considering prescribing Propofol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Magnesium Sulfate Heptahydrate(Magnesium Sulfate)+💊 Propofol(Propofol)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
General Anesthetic
Source
NLP:magnesium sulfate heptahydrate

What this means in plain English

Potentiation and prolongation of analgesia and CNS depression is possible. Monitor depth of CNS depression frequently and adjust dosage accordingly.

What the FDA label says

"Antagonism of N-methyl-D-aspartate (NMDA) by magnesium sulfate"

📖 Source: NLP:magnesium sulfate heptahydrate

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Magnesium Sulfate Heptahydrate and Propofol against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.