Does Mao Inhibitors Interact with Amlodipine And Valsartan?
CDI records a major classification for Mao Inhibitors and Amlodipine And Valsartan. The stored summary is: In elderly, volume-depleted, or renally impaired patients, coadministration may result in deterioration of renal function including possible acute renal failure. May attenuate antihypertensive effect. Monitor renal function. The mechanism involves cox-2 inhibitors reduce renal perfusion and may antagonize valsartan's mechanism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Amlodipine And Valsartan Class
- Angiotensin 2 Receptor Blocker
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
COX-2 inhibitors reduce renal perfusion and may antagonize valsartan's mechanism
What To Tell Your Doctor or Pharmacist
If you are taking Mao Inhibitors and your doctor is considering prescribing Amlodipine And Valsartan (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider