Mao Inhibitors + Amlodipine And Valsartan Interaction

Majorinteraction on record

Description

In elderly, volume-depleted, or renally impaired patients, coadministration may result in deterioration of renal function including possible acute renal failure. May attenuate antihypertensive effect. Monitor renal function.

Mechanism

COX-2 inhibitors reduce renal perfusion and may antagonize valsartan's mechanism

Source: NLP:amlodipine and valsartan