Mao Inhibitors + Avutometinib Potassium And Defactinib Hydrochloride Interaction

Majorinteraction on record

Description

Concomitant use increases defactinib exposure, which may increase the risk of adverse reactions. Avoid concomitant use.

Mechanism

Defactinib is a CYP3A4 substrate; inhibition increases exposure

Source: NLP:avutometinib potassium and defactinib hydrochloride