Mao Inhibitors + Letrozole And Ribociclib Interaction
Majorinteraction on record
Description
Strong CYP3A4 inhibitors increase ribociclib exposure and may increase incidence and severity of adverse reactions including QTcF prolongation. Dose reduction required if coadministration cannot be avoided.
Mechanism
CYP3A4 inhibition increases ribociclib plasma concentrations
Source: NLP:letrozole and ribociclib