Medroxyprogesterone Acetate Suspension + Pegvaliase Pqpz Interaction
Majorinteraction on record
Description
Concomitant use may cause hypersensitivity reactions including anaphylaxis. Two patients experienced hypersensitivity reactions within 10-15 minutes of medroxyprogesterone acetate injection after PEGVALIASE-PQPZ dosing, with one progressing to anaphylaxis.
Mechanism
Anti-PEG IgG antibody formation from PEGVALIASE-PQPZ may cross-react with PEG-containing formulations like medroxyprogesterone acetate suspension (PEG 3350)
Source: NLP:pegvaliase-pqpz