Home›Metoprolol›Metoprolol + Clonidine

Does Metoprolol Interact with Clonidine?

Metoprolol and Clonidine have a major drug interaction according to U.S. FDA drug labeling data. Increases bradycardia risk; beta-blockers may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before gradual clonidine withdrawal. The mechanism involves additive negative chronotropic effect and risk of rebound hypertension. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Clonidine Class
Central alpha-2 Adrenergic Agonist
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Metoprolol and Clonidine occurs because additive negative chronotropic effect and risk of rebound hypertension. Clinically, this means increases bradycardia risk; beta-blockers may exacerbate rebound hypertension following clonidine withdrawal. withdraw metoprolol several days before gradual clonidine withdrawal. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Metoprolol and your doctor is considering prescribing Clonidine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Metoprolol+💊 Clonidine(Clonidine)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Central alpha-2 Adrenergic Agonist
Source
NLP:metoprolol

What this means in plain English

Increases bradycardia risk; beta-blockers may exacerbate rebound hypertension following clonidine withdrawal. Withdraw metoprolol several days before gradual clonidine withdrawal.

What the FDA label says

"Additive negative chronotropic effect and risk of rebound hypertension"

📖 Source: NLP:metoprolol

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Metoprolol and Clonidine against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.