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Does Metronidazole Interact with Dronabinol?

Metronidazole and Dronabinol have a contraindicated drug interaction according to U.S. FDA drug labeling data. Dronabinol oral solution contains alcohol which produces disulfiram-like reactions when co-administered with metronidazole. Discontinue metronidazole at least 14 days before starting dronabinol and do not administer within 7 days of completing treatment. The mechanism involves disulfiram-like reaction due to alcohol content in dronabinol oral solution. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Metronidazole Class
Nitroimidazole Antimicrobial
Dronabinol Class
Cannabinoid
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Metronidazole and Dronabinol occurs because disulfiram-like reaction due to alcohol content in dronabinol oral solution. Clinically, this means dronabinol oral solution contains alcohol which produces disulfiram-like reactions when co-administered with metronidazole. discontinue metronidazole at least 14 days before starting dronabinol and do not administer within 7 days of completing treatment. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Metronidazole and your doctor is considering prescribing Dronabinol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Metronidazole(Rosadan)+💊 Dronabinol(Syndros)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Nitroimidazole Antimicrobial
Drug B class
Cannabinoid
Source
NLP:dronabinol

What this means in plain English

Dronabinol oral solution contains alcohol which produces disulfiram-like reactions when co-administered with metronidazole. Discontinue metronidazole at least 14 days before starting dronabinol and do not administer within 7 days of completing treatment.

About Metronidazole and Dronabinol

Metronidazole is a Nitroimidazole Antimicrobial, while Dronabinol is a Cannabinoid. You may recognize them by the brand names Rosadan and Syndros. Metronidazole is applied to the skin, whereas Dronabinol is taken by mouth. Metronidazole additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Disulfiram-like reaction due to alcohol content in dronabinol oral solution"

📖 Source: NLP:dronabinol

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.