Does Mexiletine Hydrochloride Interact with Digoxin?
Mexiletine Hydrochloride and Digoxin have a minor drug interaction according to U.S. FDA drug labeling data. ECG intervals were not affected by concurrent mexiletine and digoxin; mexiletine does not alter serum digoxin levels. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Digoxin Class
- Cardiac Glycoside
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Mexiletine Hydrochloride and your doctor is considering prescribing Digoxin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider