Mexiletine Hydrochloride has 12 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Theophylline, Antacids (Aluminum- Or Magnesium-Containing), Cimetidine. Patients taking Mexiletine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 12
- Major
- 1
- Moderate
- 7
- Minor
- 4
Major (1)
- Mexiletine Hydrochloride + Theophylline— Concurrent use may lead to significantly increased plasma theophylline levels (mean 72% increase). Theophylline blood le…
Moderate (7)
- Mexiletine Hydrochloride + Antacids (Aluminum- Or Magnesium-Containing)— Used to treat mexiletine-induced gastrointestinal symptoms but has been reported to lower serum digoxin levels.
- Mexiletine Hydrochloride + Cimetidine— Reported to increase, decrease, or leave unchanged mexiletine plasma levels; careful patient monitoring required.
- Mexiletine Hydrochloride + Fluvoxamine— CYP1A2 inhibitor that decreases mexiletine clearance by 38%, requiring dose titration.
- Mexiletine Hydrochloride + Phenobarbital— Hepatic enzyme inducer that lowers mexiletine plasma levels; monitoring recommended to avoid ineffective therapy.
- Mexiletine Hydrochloride + Phenytoin— Hepatic enzyme inducer that lowers mexiletine plasma levels; monitoring recommended to ensure therapeutic efficacy.
- Mexiletine Hydrochloride + Propafenone— Decreases mexiletine metabolic clearance by about 70% in extensive CYP2D6 metabolizers; dose titration recommended.
- Mexiletine Hydrochloride + Rifampin— Hepatic enzyme inducer that lowers mexiletine plasma levels; monitoring recommended to avoid ineffective therapy.
Minor (4)
- Mexiletine Hydrochloride + Digoxin— ECG intervals were not affected by concurrent mexiletine and digoxin; mexiletine does not alter serum digoxin levels.
- Mexiletine Hydrochloride + Nitrazepam— Formal study showed benzodiazepines do not affect mexiletine plasma concentrations.
- Mexiletine Hydrochloride + Propranolol— ECG intervals were not affected by concurrent mexiletine and propranolol administration.
- Mexiletine Hydrochloride + Quinidine— Antiarrhythmic drug used concurrently with mexiletine in compassionate use program with sometimes improved ventricular e…