Does Mexiletine Hydrochloride Interact with Fluvoxamine?
Mexiletine Hydrochloride and Fluvoxamine have a moderate drug interaction according to U.S. FDA drug labeling data. CYP1A2 inhibitor that decreases mexiletine clearance by 38%, requiring dose titration. The mechanism involves inhibition of cyp1a2 enzyme. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Mexiletine Hydrochloride and Fluvoxamine occurs because inhibition of cyp1a2 enzyme. Clinically, this means cyp1a2 inhibitor that decreases mexiletine clearance by 38%, requiring dose titration. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Mexiletine Hydrochloride and your doctor is considering prescribing Fluvoxamine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider