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Does Mexiletine Hydrochloride Interact with Propafenone?

CDI records a moderate classification for Mexiletine Hydrochloride and Propafenone. The stored summary is: Decreases mexiletine metabolic clearance by about 70% in extensive CYP2D6 metabolizers; dose titration recommended. The mechanism involves inhibition of cyp2d6 enzyme. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity
Moderate
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

Recorded Mechanism

Inhibition of CYP2D6 enzyme

What To Tell Your Doctor or Pharmacist

If you are taking Mexiletine Hydrochloride and your doctor is considering prescribing Propafenone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Mexiletine Hydrochloride(Mexiletine Hydrochloride)+💊 Propafenone(Propafenone Hydrochloride)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:mexiletine hydrochloride

What this means in plain English

Decreases mexiletine metabolic clearance by about 70% in extensive CYP2D6 metabolizers; dose titration recommended.

About Mexiletine Hydrochloride and Propafenone

Both Mexiletine Hydrochloride and Propafenone carry an FDA boxed warning — the agency's most serious safety designation.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:mexiletine hydrochloride

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.

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