Does Midazolam In 08 Sodium Chloride Interact with Itraconazole?
CDI records a moderate classification for Midazolam In 08 Sodium Chloride and Itraconazole. The stored summary is: P450-3A4 inhibitor may result in prolonged sedation due to decreased plasma clearance of midazolam. The mechanism involves inhibition of cytochrome p450-3a4 enzyme system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Midazolam In 08 Sodium Chloride Class
- Benzodiazepine
- Itraconazole Class
- Azole Antifungal
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of cytochrome P450-3A4 enzyme system
What To Tell Your Doctor or Pharmacist
If you are taking Midazolam In 08 Sodium Chloride and your doctor is considering prescribing Itraconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider