Does Midodrine Hydrochloride Interact with Triamterene?
Midodrine Hydrochloride and Triamterene have a unknown drug interaction according to U.S. FDA drug labeling data. Potential for drug-drug interaction due to possible competition for active tubular secretion via base-secreting system. The mechanism involves potential competition for renal tubular secretion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Triamterene Class
- Potassium-sparing Diuretic
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Midodrine Hydrochloride and Triamterene occurs because potential competition for renal tubular secretion. Clinically, this means potential for drug-drug interaction due to possible competition for active tubular secretion via base-secreting system.
What To Tell Your Doctor or Pharmacist
If you are taking Midodrine Hydrochloride and your doctor is considering prescribing Triamterene (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider