Home›Modafinil›Modafinil + Omeprazole

Does Modafinil Interact with Omeprazole?

The modafinil label names omeprazole among CYP2C19 substrates whose elimination may slow and exposure may increase during coadministration.

Label evidence and limitations

Named-drug label evidence. The label discusses possible clinician-directed dose adjustment. An omeprazole study elsewhere in this label used armodafinil; its numerical result should not be attributed to a modafinil study.

Product scope: Oral modafinil tablets.

Read the DailyMed label: These highlights do not include all the information needed to use MODAFINIL TABLETS safely and effectively. See full prescribing information for MODAFINIL TABLETS. MODAFINIL tablets, for oral use, C-IV Initial U.S. Approval: 1998
Section: 7 Drug Interactions — CYP2C19 substrates. Compared version 14, label date 2026-09-03. The linked label may be updated after this comparison.

The original record has no saved label identifier. This comparison uses a label located during the source check; it does not recover the original extraction source.

AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.

Stored CDI classification: Moderate
Modafinil Class: Sympathomimetic-like Agent
Omeprazole Class: Proton Pump Inhibitor
Management: Confirm exact products with your pharmacist
Data Source: Product label via NLM DailyMed

What To Tell Your Doctor or Pharmacist

If you are taking Modafinil and your doctor is considering prescribing Omeprazole (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Modafinil(Provigil)+💊 Omeprazole(Yosprala)

Severity & Interaction Details

🟡

Stored CDI classification: moderate

Named-drug label evidence

The label discusses possible clinician-directed dose adjustment. An omeprazole study elsewhere in this label used armodafinil; its numerical result should not be attributed to a modafinil study.

Stored CDI scale

MinorContra

On record

Yes

Drug A class

Sympathomimetic-like Agent

Drug B class

Proton Pump Inhibitor

Source

NLP:modafinil

How to interpret this source comparison

The label discusses possible clinician-directed dose adjustment. An omeprazole study elsewhere in this label used armodafinil; its numerical result should not be attributed to a modafinil study.

About Modafinil and Omeprazole

Modafinil is a Sympathomimetic-like Agent, while Omeprazole is a Proton Pump Inhibitor. You may recognize them by the brand names Provigil and Yosprala.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:modafinil

Share this result:

WhatsApp Text / SMS Email

Also share on:X Facebook

Add more drugs

Check Modafinil and Omeprazole against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.