Does Mometasone Interact with Cobicistat?
Mometasone and Cobicistat have a moderate drug interaction according to U.S. FDA drug labeling data. Strong CYP3A4 inhibitor (cobicistat-containing products) may increase systemic exposure to mometasone and risk of systemic corticosteroid side effects; caution advised. The mechanism involves inhibition of cyp3a4-mediated metabolism of mometasone. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Cobicistat Class
- Cytochrome P450 3A Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Mometasone and Cobicistat occurs because inhibition of cyp3a4-mediated metabolism of mometasone. Clinically, this means strong cyp3a4 inhibitor (cobicistat-containing products) may increase systemic exposure to mometasone and risk of systemic corticosteroid side effects; caution advised. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Mometasone and your doctor is considering prescribing Cobicistat (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider