Home›Monoamine Oxidase Inhibitors Maois›Monoamine Oxidase Inhibitors Maois + Brompheniramine Maleate Pseudoephedrine Hydrochloride

Does Monoamine Oxidase Inhibitors Maois Interact with Brompheniramine Maleate Pseudoephedrine Hydrochloride?

Monoamine Oxidase Inhibitors Maois and Brompheniramine Maleate Pseudoephedrine Hydrochloride have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant administration should be avoided. MAO inhibitors prolong and intensify anticholinergic effects of brompheniramine and may enhance pseudoephedrine effects. The mechanism involves mao inhibitors prolong and intensify anticholinergic effects of antihistamines and enhance sympathomimetic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Monoamine Oxidase Inhibitors Maois and Brompheniramine Maleate Pseudoephedrine Hydrochloride occurs because mao inhibitors prolong and intensify anticholinergic effects of antihistamines and enhance sympathomimetic effects. Clinically, this means concomitant administration should be avoided. mao inhibitors prolong and intensify anticholinergic effects of brompheniramine and may enhance pseudoephedrine effects. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Monoamine Oxidase Inhibitors Maois and your doctor is considering prescribing Brompheniramine Maleate Pseudoephedrine Hydrochloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Monoamine Oxidase Inhibitors Maois+💊 Brompheniramine Maleate Pseudoephedrine Hydrochloride(Brompheniramine Maleate, Pseudoephedrine Hydrochloride,)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:brompheniramine maleate, pseudoephedrine hydrochloride,

What this means in plain English

Concomitant administration should be avoided. MAO inhibitors prolong and intensify anticholinergic effects of brompheniramine and may enhance pseudoephedrine effects.

What the FDA label says

"MAO inhibitors prolong and intensify anticholinergic effects of antihistamines and enhance sympathomimetic effects"

📖 Source: NLP:brompheniramine maleate, pseudoephedrine hydrochloride,

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.