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Does Monoamine Oxidase Inhibitors Maois Interact with Solriamfetol?

Monoamine Oxidase Inhibitors Maois and Solriamfetol have a contraindicated drug interaction according to U.S. FDA drug labeling data. Do not administer SUNOSI concomitantly with MAOIs or within 14 days after discontinuing MAOI treatment. Concomitant use may increase risk of hypertensive reaction with serious outcomes including death, stroke, myocardial infarction, and aortic dissection. The mechanism involves mao inhibitors and noradrenergic drugs may increase the risk of a hypertensive reaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Solriamfetol Class
Dopamine and Norepinephrine Reuptake Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Monoamine Oxidase Inhibitors Maois and Solriamfetol occurs because mao inhibitors and noradrenergic drugs may increase the risk of a hypertensive reaction. Clinically, this means do not administer sunosi concomitantly with maois or within 14 days after discontinuing maoi treatment. concomitant use may increase risk of hypertensive reaction with serious outcomes including death, stroke, myocardial infarction, and aortic dissection. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Monoamine Oxidase Inhibitors Maois and your doctor is considering prescribing Solriamfetol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Monoamine Oxidase Inhibitors Maois+💊 Solriamfetol(Sunosi)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Dopamine and Norepinephrine Reuptake Inhibitor
Source
NLP:solriamfetol

What this means in plain English

Do not administer SUNOSI concomitantly with MAOIs or within 14 days after discontinuing MAOI treatment. Concomitant use may increase risk of hypertensive reaction with serious outcomes including death, stroke, myocardial infarction, and aortic dissection.

What the FDA label says

"MAO inhibitors and noradrenergic drugs may increase the risk of a hypertensive reaction"

📖 Source: NLP:solriamfetol

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.