Does Naltrexone Hydrochloride And Bupropion Hydrochloride Interact with Clopidogrel?
Naltrexone Hydrochloride And Bupropion Hydrochloride and Clopidogrel have a moderate drug interaction according to U.S. FDA drug labeling data. CYP2B6 inhibitor that can increase bupropion exposure. Do not exceed one tablet twice daily when taken with clopidogrel. The mechanism involves cyp2b6 inhibition reducing bupropion metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Clopidogrel Class
- P2Y12 Platelet Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Naltrexone Hydrochloride And Bupropion Hydrochloride and Clopidogrel occurs because cyp2b6 inhibition reducing bupropion metabolism. Clinically, this means cyp2b6 inhibitor that can increase bupropion exposure. do not exceed one tablet twice daily when taken with clopidogrel. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Naltrexone Hydrochloride And Bupropion Hydrochloride and your doctor is considering prescribing Clopidogrel (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider