Does Nelfinavir Interact with Omeprazole?
CDI records a contraindicated classification for Nelfinavir and Omeprazole. The stored summary is: Omeprazole reduces plasma levels of nelfinavir significantly (AUC decreased by 92%), which may result in loss of therapeutic effect and development of drug resistance. Concomitant use is not recommended. The mechanism involves increased gastric ph during omeprazole treatment may change absorption of nelfinavir. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Omeprazole Class
- Proton Pump Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased gastric pH during omeprazole treatment may change absorption of nelfinavir
What To Tell Your Doctor or Pharmacist
If you are taking Nelfinavir and your doctor is considering prescribing Omeprazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider