Does Nitroglycerin Interact with Aspirin?
Nitroglycerin and Aspirin have a moderate drug interaction according to U.S. FDA drug labeling data. Increases nitroglycerin maximum concentrations by up to 67% and AUC by 73%, potentially enhancing pharmacological effects. Monitor closely. The mechanism involves increased nitroglycerin bioavailability and exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Nitroglycerin Class
- Nitrate Vasodilator
- Aspirin Class
- Nonsteroidal Anti-inflammatory Drug [EPC]
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nitroglycerin and Aspirin occurs because increased nitroglycerin bioavailability and exposure. Clinically, this means increases nitroglycerin maximum concentrations by up to 67% and auc by 73%, potentially enhancing pharmacological effects. monitor closely. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Nitroglycerin and your doctor is considering prescribing Aspirin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider