Home›Nizatidine›Nizatidine + Tadalafil

Does Nizatidine Interact with Tadalafil?

Nizatidine and Tadalafil have a minor drug interaction according to U.S. FDA drug labeling data. Increase in gastric pH from nizatidine had no significant effect on tadalafil pharmacokinetics. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Nizatidine Class
Histamine-2 Receptor Antagonist
Tadalafil Class
Phosphodiesterase 5 Inhibitor
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Nizatidine and your doctor is considering prescribing Tadalafil (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Nizatidine(Nizatidine)+💊 Tadalafil(Alyq)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
Histamine-2 Receptor Antagonist
Drug B class
Phosphodiesterase 5 Inhibitor
Source
NLP:tadalafil

What this means in plain English

Increase in gastric pH from nizatidine had no significant effect on tadalafil pharmacokinetics.

About Nizatidine and Tadalafil

Nizatidine is a Histamine-2 Receptor Antagonist, while Tadalafil is a Phosphodiesterase 5 Inhibitor. Tadalafil is also sold under the brand name Alyq. Both medications are taken by mouth. Tadalafil additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Nizatidine and Tadalafil against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.