Does Nonsteroidal Anti Inflammatory Drugs Nsaids Interact with Candesartan Cilexetil And Hydrochlorothiazide?
Nonsteroidal Anti Inflammatory Drugs Nsaids and Candesartan Cilexetil And Hydrochlorothiazide have a major drug interaction according to U.S. FDA drug labeling data. Co-administration may result in deterioration of renal function, including possible acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. NSAIDs may attenuate antihypertensive effect. The mechanism involves renal function compromise through angiotensin ii receptor antagonism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Candesartan Cilexetil And Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nonsteroidal Anti Inflammatory Drugs Nsaids and Candesartan Cilexetil And Hydrochlorothiazide occurs because renal function compromise through angiotensin ii receptor antagonism. Clinically, this means co-administration may result in deterioration of renal function, including possible acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. nsaids may attenuate antihypertensive effect. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Nonsteroidal Anti Inflammatory Drugs Nsaids and your doctor is considering prescribing Candesartan Cilexetil And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider