Does Nonsteroidal Anti Inflammatory Drugs Nsaids Interact with Ofloxacin?
Nonsteroidal Anti Inflammatory Drugs Nsaids and Ofloxacin have a major drug interaction according to U.S. FDA drug labeling data. Concomitant NSAIDs with ofloxacin may increase risk of CNS stimulation and convulsive seizures. The mechanism involves additive cns effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Ofloxacin Class
- Quinolone Antimicrobial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nonsteroidal Anti Inflammatory Drugs Nsaids and Ofloxacin occurs because additive cns effects. Clinically, this means concomitant nsaids with ofloxacin may increase risk of cns stimulation and convulsive seizures. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Nonsteroidal Anti Inflammatory Drugs Nsaids and your doctor is considering prescribing Ofloxacin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider