Does Olanzapine And Samidorphan L Malate Interact with Levodopa?
CDI records a major classification for Olanzapine And Samidorphan L Malate and Levodopa. The stored summary is: Concomitant use is not recommended due to dopamine antagonism by olanzapine potentially reducing levodopa efficacy. The mechanism involves dopamine antagonism by olanzapine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Olanzapine And Samidorphan L Malate Class
- Atypical Antipsychotic
- Levodopa Class
- Aromatic Amino Acid
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Dopamine antagonism by olanzapine
What To Tell Your Doctor or Pharmacist
If you are taking Olanzapine And Samidorphan L Malate and your doctor is considering prescribing Levodopa (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider