Does Olmesartan Medoxomil Interact with Aliskiren?
CDI records a contraindicated classification for Olmesartan Medoxomil and Aliskiren. The stored summary is: Co-administration contraindicated in patients with diabetes. Avoid in patients with renal impairment (GFR <60 ml/min). Associated with increased risks of hypotension, hyperkalemia, and acute renal failure. The mechanism involves dual ras blockade increasing hypotension, hyperkalemia, and renal dysfunction risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Dual RAS blockade increasing hypotension, hyperkalemia, and renal dysfunction risk
What To Tell Your Doctor or Pharmacist
If you are taking Olmesartan Medoxomil and your doctor is considering prescribing Aliskiren (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider