Does Omeprazole Interact with Cysteamine Bitartrate?
Omeprazole and Cysteamine Bitartrate have a minor drug interaction according to U.S. FDA drug labeling data. Concomitant administration of 20 mg omeprazole did not affect the pharmacokinetics of cysteamine when PROCYSBI was administered with orange juice or water. The mechanism involves drug that increases gastric ph. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Omeprazole Class
- Proton Pump Inhibitor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Omeprazole and Cysteamine Bitartrate occurs because drug that increases gastric ph. Clinically, this means concomitant administration of 20 mg omeprazole did not affect the pharmacokinetics of cysteamine when procysbi was administered with orange juice or water. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Omeprazole and your doctor is considering prescribing Cysteamine Bitartrate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider