Does Omeprazole And Sodium Bicarbonate Interact with Clarithromycin?
Omeprazole And Sodium Bicarbonate and Clarithromycin have a contraindicated drug interaction according to U.S. FDA drug labeling data. 7.4 Combination Therapy with Clarithromycin Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions due to drug interaction [ See Warnings and Precautions in prescribing information for clarithromycin]. Because of these drug interactions, clarithromycin is contraindicated for co-administration with certain drugs [ See Contraindications in prescribing information for clarithromycin.] 7.5 Clopidogrel Omeprazole is an inhibitor of CYP2C19 enzyme. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Omeprazole And Sodium Bicarbonate Class
- Proton Pump Inhibitor
- Clarithromycin Class
- Macrolide Antimicrobial
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Omeprazole And Sodium Bicarbonate and your doctor is considering prescribing Clarithromycin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider