Does Omeprazole And Sodium Bicarbonate Interact with Phenytoin?
CDI records a moderate classification for Omeprazole And Sodium Bicarbonate and Phenytoin. The stored summary is: CYP2C19 substrate; concomitant use with omeprazole may increase exposure due to inhibition of CYP2C19. The mechanism involves cyp2c19 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Omeprazole And Sodium Bicarbonate Class
- Proton Pump Inhibitor
- Phenytoin Class
- Anti-epileptic Agent
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP2C19 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Omeprazole And Sodium Bicarbonate and your doctor is considering prescribing Phenytoin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider