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Does Oxycodone And Acetaminophen Interact with Metaxalone?

Oxycodone And Acetaminophen and Metaxalone have a contraindicated drug interaction according to U.S. FDA drug labeling data. Muscle relaxant CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death. The mechanism involves additive cns depression. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Oxycodone And Acetaminophen Class
Opioid Agonist
Metaxalone Class
Muscle Relaxant
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Oxycodone And Acetaminophen and Metaxalone occurs because additive cns depression. Clinically, this means muscle relaxant cns depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Oxycodone And Acetaminophen and your doctor is considering prescribing Metaxalone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Oxycodone And Acetaminophen(Oxycodone And Acetaminophen)+💊 Metaxalone(Metaxalone)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Opioid Agonist
Drug B class
Muscle Relaxant
Source
NLP:oxycodone and acetaminophen

What this means in plain English

Muscle relaxant CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death.

What the FDA label says

"Additive CNS depression"

📖 Source: NLP:oxycodone and acetaminophen

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.