Does Oxycodone And Acetaminophen Interact with Metaxalone?
CDI records a contraindicated classification for Oxycodone And Acetaminophen and Metaxalone. The stored summary is: Muscle relaxant CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and death. The mechanism involves additive cns depression. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Oxycodone And Acetaminophen Class
- Opioid Agonist
- Metaxalone Class
- Muscle Relaxant
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Additive CNS depression
What To Tell Your Doctor or Pharmacist
If you are taking Oxycodone And Acetaminophen and your doctor is considering prescribing Metaxalone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider