Does Pentazocine Hydrochloride And Naloxone Hydrochloride Interact with Anakinra?
CDI records a major classification for Pentazocine Hydrochloride And Naloxone Hydrochloride and Anakinra. The stored summary is: Concomitant use has resulted in serotonin syndrome. Carefully observe patient during treatment initiation and dose adjustment. The mechanism involves additive effects on serotonergic neurotransmitter system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Pentazocine Hydrochloride And Naloxone Hydrochloride Class
- Partial Opioid Agonist/Antagonist
- Anakinra Class
- Interleukin-1 Receptor Antagonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Additive effects on serotonergic neurotransmitter system
What To Tell Your Doctor or Pharmacist
If you are taking Pentazocine Hydrochloride And Naloxone Hydrochloride and your doctor is considering prescribing Anakinra (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider