Does Phenytoin Interact with Brivaracetam Injection?
Phenytoin and Brivaracetam Injection have a moderate drug interaction according to U.S. FDA drug labeling data. Brivaracetam can increase plasma concentrations of phenytoin; phenytoin levels should be monitored when brivaracetam is added or discontinued. The mechanism involves increased phenytoin plasma concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Phenytoin Class
- Anti-epileptic Agent
- Brivaracetam Injection Class
- Epoxide Hydrolase Inhibitors
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Phenytoin and Brivaracetam Injection occurs because increased phenytoin plasma concentrations. Clinically, this means brivaracetam can increase plasma concentrations of phenytoin; phenytoin levels should be monitored when brivaracetam is added or discontinued. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Phenytoin and your doctor is considering prescribing Brivaracetam Injection (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider