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Does Brivaracetam Injection Interact with Carbamazepine?

Brivaracetam Injection and Carbamazepine have a moderate drug interaction according to U.S. FDA drug labeling data. Brivaracetam may increase exposure to carbamazepine-epoxide (active metabolite); carbamazepine dose reduction should be considered if tolerability issues arise. The mechanism involves increased metabolism of carbamazepine to active metabolite. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Brivaracetam Injection Class
Epoxide Hydrolase Inhibitors
Carbamazepine Class
Mood Stabilizer
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Brivaracetam Injection and Carbamazepine occurs because increased metabolism of carbamazepine to active metabolite. Clinically, this means brivaracetam may increase exposure to carbamazepine-epoxide (active metabolite); carbamazepine dose reduction should be considered if tolerability issues arise. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Brivaracetam Injection and your doctor is considering prescribing Carbamazepine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Brivaracetam Injection(Brivaracetam)+💊 Carbamazepine(Tegretol)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Epoxide Hydrolase Inhibitors
Drug B class
Mood Stabilizer
Source
NLP:brivaracetam injection

What this means in plain English

Brivaracetam may increase exposure to carbamazepine-epoxide (active metabolite); carbamazepine dose reduction should be considered if tolerability issues arise.

About Brivaracetam Injection and Carbamazepine

Brivaracetam Injection is an Epoxide Hydrolase Inhibitors, while Carbamazepine is a Mood Stabilizer. Carbamazepine is also sold under the brand name Tegretol. Brivaracetam Injection is given by intravenous (IV) infusion, whereas Carbamazepine is taken by mouth. Carbamazepine additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Increased metabolism of carbamazepine to active metabolite"

📖 Source: NLP:brivaracetam injection

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.