Does Brivaracetam Injection Interact with Carbamazepine?
CDI records a moderate classification for Brivaracetam Injection and Carbamazepine. The stored summary is: Brivaracetam may increase exposure to carbamazepine-epoxide (active metabolite); carbamazepine dose reduction should be considered if tolerability issues arise. The mechanism involves increased metabolism of carbamazepine to active metabolite. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Brivaracetam Injection Class
- Epoxide Hydrolase Inhibitors
- Carbamazepine Class
- Mood Stabilizer
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased metabolism of carbamazepine to active metabolite
What To Tell Your Doctor or Pharmacist
If you are taking Brivaracetam Injection and your doctor is considering prescribing Carbamazepine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider