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Does Probenecid Interact with Piperacillin And Tazobactam?

Probenecid and Piperacillin And Tazobactam have a contraindicated drug interaction according to U.S. FDA drug labeling data. Probenecid prolongs half-lives of piperacillin by 21% and tazobactam by 71%. Should not be co-administered unless benefit outweighs risk. The mechanism involves probenecid inhibits tubular renal secretion of piperacillin and tazobactam. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Contraindicated
Management: Do not take together
Data Source: U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Probenecid and Piperacillin And Tazobactam occurs because probenecid inhibits tubular renal secretion of piperacillin and tazobactam. Clinically, this means probenecid prolongs half-lives of piperacillin by 21% and tazobactam by 71%. should not be co-administered unless benefit outweighs risk. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Probenecid and your doctor is considering prescribing Piperacillin And Tazobactam (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask about alternative medications that do not interact with your current regimen
Ask how frequently you should be monitored while these are co-prescribed
Never stop or change either medication without first consulting your healthcare provider

💊 Probenecid(Orlynvah)+💊 Piperacillin And Tazobactam(Zosyn)

Severity & Interaction Details

⛔

contraindicated

Avoid this combination

FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

NLP:piperacillin sodium and tazobactam sodium

What this means in plain English

Probenecid prolongs half-lives of piperacillin by 21% and tazobactam by 71%. Should not be co-administered unless benefit outweighs risk.

About Probenecid and Piperacillin And Tazobactam

You may recognize them by the brand names Orlynvah and Zosyn. Probenecid is taken by mouth, whereas Piperacillin And Tazobactam is given by intravenous (IV) infusion. Piperacillin And Tazobactam additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Probenecid inhibits tubular renal secretion of piperacillin and tazobactam"

📖 Source: NLP:piperacillin sodium and tazobactam sodium

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.