Does Revefenacin Interact with Rifampin?
CDI records a major classification for Revefenacin and Rifampin. The stored summary is: OATP1B1 and OATP1B3 inhibitor that may increase systemic exposure of revefenacin's active metabolite. Coadministration not recommended. The mechanism involves inhibition of oatp1b1 and oatp1b3 transporters. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Revefenacin Class
- Anticholinergic
- Rifampin Class
- Rifamycin Antibacterial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of OATP1B1 and OATP1B3 transporters
What To Tell Your Doctor or Pharmacist
If you are taking Revefenacin and your doctor is considering prescribing Rifampin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider