Does Ribavirin Interact with Abacavir Lamivudine And Zidovudine?
Ribavirin and Abacavir Lamivudine And Zidovudine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use with zidovudine should be avoided due to demonstrated in vitro antagonistic relationship and increased hematologic toxicity risk. The mechanism involves antagonistic relationship and bone marrow suppression. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Ribavirin Class
- Nucleoside Analog Antiviral
- Abacavir Lamivudine And Zidovudine Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ribavirin and Abacavir Lamivudine And Zidovudine occurs because antagonistic relationship and bone marrow suppression. Clinically, this means concomitant use with zidovudine should be avoided due to demonstrated in vitro antagonistic relationship and increased hematologic toxicity risk. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.
What To Tell Your Doctor or Pharmacist
If you are taking Ribavirin and your doctor is considering prescribing Abacavir Lamivudine And Zidovudine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider