Does Rifabutin Interact with Delavirdine?
CDI records a contraindicated classification for Rifabutin and Delavirdine. The stored summary is: Delavirdine increases rifabutin AUC by 230% and Cmax by 128%, while rifabutin reduces delavirdine concentrations by 80%. Interaction is contraindicated. The mechanism involves cyp3a inhibition and induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Rifabutin Class
- Rifamycin Antimycobacterial
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A inhibition and induction
What To Tell Your Doctor or Pharmacist
If you are taking Rifabutin and your doctor is considering prescribing Delavirdine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider