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Does Rosuvastatin Calcium Interact with Gemfibrozil?

Rosuvastatin Calcium and Gemfibrozil have a contraindicated drug interaction according to U.S. FDA drug labeling data. Combination should be avoided due to increased risk of myopathy/rhabdomyolysis. If used together, limit rosuvastatin to 10 mg once daily. The mechanism involves significantly increased rosuvastatin exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Gemfibrozil Class
Peroxisome Proliferator Receptor alpha Agonist
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Rosuvastatin Calcium and Gemfibrozil occurs because significantly increased rosuvastatin exposure. Clinically, this means combination should be avoided due to increased risk of myopathy/rhabdomyolysis. if used together, limit rosuvastatin to 10 mg once daily. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Rosuvastatin Calcium and your doctor is considering prescribing Gemfibrozil (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Rosuvastatin Calcium(Crestor)+💊 Gemfibrozil(Lopid)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Peroxisome Proliferator Receptor alpha Agonist
Source
NLP:rosuvastatin calcium

What this means in plain English

Combination should be avoided due to increased risk of myopathy/rhabdomyolysis. If used together, limit rosuvastatin to 10 mg once daily.

About Rosuvastatin Calcium and Gemfibrozil

Gemfibrozil is a Peroxisome Proliferator Receptor alpha Agonist. You may recognize them by the brand names Crestor and Lopid. Both medications are taken by mouth. Gemfibrozil additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Significantly increased rosuvastatin exposure"

📖 Source: NLP:rosuvastatin calcium

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.