Rosuvastatin Calcium has 41 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 25 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Gemfibrozil, Ledipasvir And Sofosbuvir, Sofosbuvir, Velpatasvir, And Voxilaprevir. Patients taking Rosuvastatin Calcium should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 41
- Contraindicated
- 3
- Major
- 25
- Moderate
- 5
Contraindicated (3)
- Rosuvastatin Calcium + Gemfibrozil— Combination should be avoided due to increased risk of myopathy/rhabdomyolysis. If used together, limit rosuvastatin to …
- Rosuvastatin Calcium + Ledipasvir And Sofosbuvir— Combination significantly increases rosuvastatin exposure. Concomitant use is not recommended.
- Rosuvastatin Calcium + Sofosbuvir, Velpatasvir, And Voxilaprevir— Combination increases rosuvastatin exposure. Concomitant use is not recommended.
Major (25)
- Rosuvastatin Calcium + Atazanavir— Combination increases rosuvastatin exposure up to 3-fold. Limit rosuvastatin dose to 10 mg once daily.
- Rosuvastatin Calcium + Capmatinib— Capmatinib increases rosuvastatin exposure more than 2.1-fold, increasing risk of myopathy and rhabdomyolysis. Do not ex…
- Rosuvastatin Calcium + Cyclosporine— Cyclosporine increases rosuvastatin exposure 7-fold. Limit rosuvastatin dose to 5 mg once daily.
- Rosuvastatin Calcium + Darolutamide— Increases rosuvastatin exposure. Limit rosuvastatin dose to 5 mg once daily.
- Rosuvastatin Calcium + Dasabuvir/Ombitasvir/Paritaprevir/Ritonavir— Increases rosuvastatin exposure. Limit rosuvastatin dose to 10 mg once daily.
- Rosuvastatin Calcium + Elbasvir And Grazoprevir— Increases rosuvastatin exposure. Limit rosuvastatin dose to 10 mg once daily.
- Rosuvastatin Calcium + Enasidenib— Enasidenib increases rosuvastatin exposure more than 2.4-fold, increasing risk of myopathy and rhabdomyolysis. Do not ex…
- Rosuvastatin Calcium + Febuxostat— Febuxostat increases rosuvastatin exposure more than 1.9-fold, increasing risk of myopathy and rhabdomyolysis. Do not ex…
- Rosuvastatin Calcium + Fibrates— Concomitant use with fibrates increases risk of adverse skeletal muscle effects including myopathy. Caution should be us…
- Rosuvastatin Calcium + Fostamatinib— Fostamatinib increases rosuvastatin exposure more than 2.0-fold, increasing risk of myopathy and rhabdomyolysis. Do not …
- Rosuvastatin Calcium + Glecaprevir And Pibrentasvir— Increases rosuvastatin exposure. Limit rosuvastatin dose to 10 mg once daily.
- Rosuvastatin Calcium + Ledipasvir— Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin.
- Rosuvastatin Calcium + Lopinavir— Lopinavir/ritonavir combination increases rosuvastatin exposure up to 3-fold. Limit rosuvastatin calcium dose to 10 mg o…
- Rosuvastatin Calcium + Lopinavir And Ritonavir— Combination increases rosuvastatin exposure up to 3-fold. Limit rosuvastatin dose to 10 mg once daily.
- Rosuvastatin Calcium + Niacin— Lipid-modifying doses of niacin (≥1 g/day) with rosuvastatin increase risk of adverse skeletal muscle effects. Caution s…
- Rosuvastatin Calcium + Oral Anticoagulants— Rosuvastatin significantly prolongs INR in patients receiving coumarin anticoagulants. Monitor INR frequently until stab…
- Rosuvastatin Calcium + Regorafenib— Increases rosuvastatin exposure. Limit rosuvastatin dose to 10 mg once daily.
- Rosuvastatin Calcium + Ritonavir— Ritonavir (in combination with atazanavir or lopinavir) increases rosuvastatin exposure up to 3-fold. Limit rosuvastatin…
- Rosuvastatin Calcium + Simeprevir— Simeprevir increases rosuvastatin exposure up to 3-fold. Limit rosuvastatin dose to 10 mg once daily.
- Rosuvastatin Calcium + Sofosbuvir— Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin. Simepre…
- Rosuvastatin Calcium + Tafamidis— Tafamidis significantly increases rosuvastatin exposure, increasing risk of myopathy and rhabdomyolysis.
- Rosuvastatin Calcium + Teriflunomide— Teriflunomide increases rosuvastatin exposure more than 2.5-fold, increasing risk of myopathy and rhabdomyolysis. Do not…
- Rosuvastatin Calcium + Velpatasvir— Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin. Simepre…
- Rosuvastatin Calcium + Velpatasvir And Sofosbuvir— Increases rosuvastatin exposure. Limit rosuvastatin dose to 10 mg once daily.
- Rosuvastatin Calcium + Voxilaprevir— Intervention: Sofosbuvir/velpatasvir/voxilaprevir Ledipasvir/sofosbuvir Avoid concomitant use with rosuvastatin.
Moderate (5)
- Rosuvastatin Calcium + Aluminum & Magnesium Hydroxides— Antacids may reduce rosuvastatin absorption. Administer rosuvastatin at least 2 hours before the antacid.
- Rosuvastatin Calcium + Fosamprenavir— HIV-1 protease inhibitor producing little or no change in rosuvastatin exposure. Caution should be exercised when coadmi…
- Rosuvastatin Calcium + Rosuvastatin— 7 DRUG INTERACTIONS See full prescribing information for details regarding concomitant use of rosuvastatin tablets with …
- Rosuvastatin Calcium + Tipranavir— HIV-1 protease inhibitor producing little or no change in rosuvastatin exposure. Caution should be exercised when coadmi…
- Rosuvastatin Calcium + Warfarin— Rosuvastatin may affect warfarin anticoagulant effect. Monitor INR frequently until stable upon initiation, dose titrati…