Does Rosuvastatin Calcium Interact with Ritonavir?
CDI records a major classification for Rosuvastatin Calcium and Ritonavir. The stored summary is: Ritonavir (in combination with atazanavir or lopinavir) increases rosuvastatin exposure up to 3-fold. Limit rosuvastatin calcium dose to 10 mg once daily. The mechanism involves increased auc (up to 3-fold). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Ritonavir Class
- Cytochrome P450 3A Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased AUC (up to 3-fold)
What To Tell Your Doctor or Pharmacist
If you are taking Rosuvastatin Calcium and your doctor is considering prescribing Ritonavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider