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Does Sacubitril And Valsartan Interact with Aliskiren?

Sacubitril And Valsartan and Aliskiren have a contraindicated drug interaction according to U.S. FDA drug labeling data. Contraindicated in patients with diabetes. Avoid use in patients with renal impairment (eGFR less than 60 mL/min/1.73 m²). The mechanism involves dual blockade of the renin-angiotensin-aldosterone system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Sacubitril And Valsartan Class
Angiotensin 2 Receptor Blocker
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Sacubitril And Valsartan and Aliskiren occurs because dual blockade of the renin-angiotensin-aldosterone system. Clinically, this means contraindicated in patients with diabetes. avoid use in patients with renal impairment (egfr less than 60 ml/min/1.73 m²). Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Sacubitril And Valsartan and your doctor is considering prescribing Aliskiren (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Sacubitril And Valsartan(Sacubitril And Valsartan)+💊 Aliskiren(Aliskiren)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Angiotensin 2 Receptor Blocker
Drug B class
—
Source
NLP:sacubitril and valsartan

What this means in plain English

Contraindicated in patients with diabetes. Avoid use in patients with renal impairment (eGFR less than 60 mL/min/1.73 m²).

What the FDA label says

"Dual blockade of the renin-angiotensin-aldosterone system"

📖 Source: NLP:sacubitril and valsartan

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.