Home›Smallpox Vaccine Vaccinia Virus›Smallpox Vaccine Vaccinia Virus + Tecovirimat Monohydrate

Does Smallpox Vaccine Vaccinia Virus Interact with Tecovirimat Monohydrate?

Smallpox Vaccine Vaccinia Virus and Tecovirimat Monohydrate have a unknown drug interaction according to U.S. FDA drug labeling data. Co-administration of TPOXX with live smallpox vaccine may reduce immune response to the vaccine. Clinical impact on vaccine efficacy is unknown. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Tecovirimat Monohydrate Class
Orthopoxvirus VP37 Envelope Wrapping Protein Inhibitor
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Smallpox Vaccine Vaccinia Virus and your doctor is considering prescribing Tecovirimat Monohydrate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Smallpox Vaccine Vaccinia Virus+💊 Tecovirimat Monohydrate(Tpoxx)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Orthopoxvirus VP37 Envelope Wrapping Protein Inhibitor
Source
NLP:tecovirimat monohydrate

What this means in plain English

Co-administration of TPOXX with live smallpox vaccine may reduce immune response to the vaccine. Clinical impact on vaccine efficacy is unknown.

About Smallpox Vaccine Vaccinia Virus and Tecovirimat Monohydrate

Tecovirimat Monohydrate is an Orthopoxvirus VP37 Envelope Wrapping Protein Inhibitor. Tecovirimat Monohydrate is also sold under the brand name Tpoxx. Tecovirimat Monohydrate is given by intravenous (IV) infusion.

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Smallpox Vaccine Vaccinia Virus and Tecovirimat Monohydrate against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.