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Does Sofosbuvir Interact with Atazanavir And Cobicistat?

Sofosbuvir and Atazanavir And Cobicistat have a unknown drug interaction according to U.S. FDA drug labeling data. Hepatitis C Antiviral Agents sofosbuvir/velpatasvir/ voxilaprevir ↑ voxilaprevir Coadministration with EVOTAZ is not recommended. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Sofosbuvir Class
Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor
Atazanavir And Cobicistat Class
Cytochrome P450 3A Inhibitor
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Sofosbuvir and your doctor is considering prescribing Atazanavir And Cobicistat (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Sofosbuvir+💊 Atazanavir And Cobicistat(Evotaz)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor
Drug B class
Cytochrome P450 3A Inhibitor
Source
FDA drug label - atazanavir and cobicistat

What this means in plain English

Hepatitis C Antiviral Agents sofosbuvir/velpatasvir/ voxilaprevir ↑ voxilaprevir Coadministration with EVOTAZ is not recommended.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.