Does Sulfamethoxazole And Trimethoprim Interact with Dapsone Gel 5?
CDI records a moderate classification for Sulfamethoxazole And Trimethoprim and Dapsone Gel 5. The stored summary is: TMP/SMX increases systemic levels of dapsone and its metabolites by approximately 40% for dapsone, 20% for N-acetyl-dapsone, and more than doubles dapsone hydroxylamine exposure. The mechanism involves inhibition of dapsone metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Sulfamethoxazole And Trimethoprim Class
- Sulfonamide Antimicrobial
- Dapsone Gel 5 Class
- Sulfone
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of dapsone metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Sulfamethoxazole And Trimethoprim and your doctor is considering prescribing Dapsone Gel 5 (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider